The present study explores the effect of chemical penetration enhancers and iontophoresis on the in vitro permeability of lisinopril across excised pig skin. Permeation studies were performed using modified franz diffusion cell. Incorporation of various permeability enhancers like dimethyl sulfoxide, peppermint oil, menthol, oleic acid, sodium louryl sulphate, poly ethylene glycol with pure drug solution showed synergistic effect when combined with iontophoresis that mean it provides an additional driving force to maintain and control the permeability of lisinopril. Steady state fluxes, permeability coefficients, diffusion coefficients, benefits and enhancement ratios by various enhancers were determined. Dimethyl sulfoxide was the most active enhancer, and when combined with iontophoresis it was possible to deliver 44.506±1.210 mmol/cm2 of drug at the end of 8 hours, it was 4.7 times enhancement as compare to delivery of drug without enhancers.
Loading....